Drugs & Vitamins

Active Ingredients: Naloxone and Pentazocine
Other Names: Naloxone Hydrochloride and Pentazocine Hydrochloride Tablets, Talwin NX Tablets
Drug Class: Narcotic Analgesics
Rx Status: Available by prescription only
Generic Available: Yes
Product Images & Descriptions:

What is/are Naloxone and Pentazocine Tablets? (Back to top)
PENTAZOCINE is a pain reliever. It is used to treat moderate to severe pain. It also contains naloxone, which is used to prevent the misuse of this medicine. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine? (Back to top)
They need to know if you have any of these conditions:

• breathing problems
• drug abuse or addiction
• head injury
• if you frequently drink alcohol containing beverages
• kidney disease
• liver disease
• seizures
• an unusual or allergic reaction to pentazocine, naloxone, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine? (Back to top)
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose? (Back to top)
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine? (Back to top)
Do not take this medicine with any of the following:

• butorphanol
• buprenorphine
• nalbuphine

• alcohol or medicines that contain alcohol
• MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
• medicines for depression like duloxetine, fluoxetine, sertraline, venlafaxine
• medicines for sleep
• other prescription medicines for pain
• procarbazine
• sibutramine

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine? (Back to top)
Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• changes in vision
• chills, flushing, sweating
• confusion, disoriented
• fast, irregular heartbeat
• feeling faint or lightheaded, falls
• hallucinations
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• tremors
• trouble passing urine or change in the amount of urine

• clumsy, unsteady
• constipation
• difficulty sleeping
• headache
• nausea, vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I watch for while using this medicine? (Back to top)
Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take the medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Where should I keep this medicine? (Back to top)
Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect them from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and is against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Last Updated:June 25, 2007

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